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Rett syndrome (RTT) is a devastating neurodevelopmental disease caused primarily by loss-of-function mutations in methyl-CpG-binding protein 2 (MECP2) (1). MeCP2 is a DNA binding protein (2) that controls gene expression, but the precise molecular mechanism by which MeCP2 loss drives RTT pathology remains unclear, partially because a distinct DNA motif that specifies MeCP2-DNA interactions is lacking. On page 1411 of this issue, Ibrahim et al. (3) demonstrate that MeCP2 binds modified cytosine in cytosine-adenine (CA) dinucleotide repeats, providing a new signature DNA motif for MeCP2 binding. MeCP2 protects CA repeats from high nucleosome occupancy, raising questions about the consequence of this binding on maintaining chromatin structure in neurons.con rich so may

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Vol 372, Issue 6549
25 June 2021

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By Jian Zhou, Huda Zoghbi

Science25 Jun 2021 : 1390-1391 con rich so may

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A motif of dinucleotide repeats in the genome may be associated with Rett syndrome

By Jian Zhou, Huda Zoghbi

Science25 Jun 2021 : 1390-1391 con rich so may

A motif of dinucleotide repeats in the genome may be associated with Rett syndrome

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Vol 372, Issue 6549con rich so may

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Science ISSN 1095-9203.

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